Wild lettuce has been historically referred to as wild “opium” lettuce because of its powerful pain-relieving effects. Studies have showed that the herb contains multiple active constituents that emit a milky white latex from the stems and leaves.

Lactucarium and lactucin sedate the central nervous system, act as a adenosine receptor agonist and favorably affect the pain center in the brain. Cramp bark and lobelia act as systemic anti-spasmodic herbs that relax muscle contraction and allow injury sites to release tension.

Hops has a powerful effect on the sympathetic nervous system, turning off fight or flight responses and allowing the body to generate a sense of calm and peace.